实验室概况
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海南省肿瘤发生和干预重点实验室简介
海南省肿瘤发生和干预重点实验室由海南省科技厅于2013年5月正式批准成立。本实验室以探索肿瘤的发病机制和干预措施为主要的研究方向。目前，实验室有专职科研人员8名，高级职称7人，具有博士学位6人, 已经培养博士研究生2人、硕士研究生12人, 在读的博士/硕士研究生15人；先后承担12项国家自然科学基金项目、2项海南省创新团队项目和多项省部级科研项目。团队成员入选“国家级百千万人才/有突出贡献中青年专家”、“教育部新世纪优秀人才支持计划”、“海南省高层次杰出人才、领军人才”、“海南省515人才工程第一层次人才”; 获得“国务院特贴专家”、“全国优秀科技工作者”、“海南省有突出贡献优秀专家”、“海南省先进工作者”和“海南青年五四奖章”等荣誉称号。本实验室研究人员在《Nature Methods》、《International Journal of Cancer》、《Cancer Letters》、《Cell Death & Disease》、《Biological Research》、《Frontiers in Immunology》、《Journal of Cellular and Molecular Medicine》等SCI收录的期刊发表科研论文40余篇。获得教育部自然科学二等奖1项、中华医学科技奖三等奖1项、海南省科技进步一、二等奖各1项。《科技日报》、《人民网》等多家媒体采访报道实验室的研究成果。
实验室长期从事的甲胎蛋白(AFP)及其受体对肝癌发生发展的作用，通过系统深入地研究, 发现了AFP除了作为肝癌标志物以外，还具有诱导肝细胞恶性增殖、耐药、迁移、侵袭和抑制凋亡等生物学功能，肝癌细胞表面的AFP受体为精准清除肝癌细胞提供了靶点。
Hainan Provincial Key Laboratory of Carcinogensis and Intervention is formally approved by the Hainan Provincial Department of Science and Technology in May, 2013. This laboratory takes focus on exploring the mechanisms of tumor occurrence and intervention strategies. The laboratory boasts a team of 8 full-time researchers, including 7 senior professionals with 6 holding doctoral degrees. It has successfully cultivated 2 doctors and 12 masters, and is currently supervising 15 doctors and masters. There are 12 projects funded by the National Natural Science Foundation, 2 projects funded by the Hainan Provincial Innovation Team, and several provincial and ministerial scientific research projects undertaken by the team members of this laboratory. They have published more than 40 scientific research papers in SCI-indexed journals including Nature Methods, International Journal of Cancer, Cancer Letters, Cell Death & Disease, Biological Researc, Frontiers in Immunology and Journal of Cellular and Molecular Medicine. This laboratory won the rewards including the second prize of the Natural Science Award of the Ministry of Education, the third prize of the Chinese Medical Science and Technology Award, and the first and second prize of the Hainan Provincial Science and Technology Progress Award. The research achievements of the laboratory have been reported by many media outlets, such as Science and Technology Daily and People's Daily Online.
The laboratory has been engaged in long-term research on the role of alpha-fetoprotein (AFP) and its receptor in the occurrence and development of liver cancer. It has been found that AFP not only serves as a diagnosis marker for liver cancer, but also has biological functions in inducing malignant proliferation, drug resistance, migration, invasion, and in inhibiting apoptosis in liver cells. The AFP receptor on the surface of liver cancer cells provides a target for precise elimination of the liver cancer cells.